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Background . The plant  Cornus mas  L. (cornelian cherry) is traditionally used as an antidiabetic supplement; however, there is no related clinical trial. In this study, we evaluated the effects of the fruit extract of this plant on biomarkers of glycemic control in adult patients with type 2 diabetes.  Methods . Sixty patients with type 2 diabetes were randomly assigned to two groups to receive either the extract or placebo capsules (2 capsules twice daily) for 6 weeks. Each drug capsule contained 150 mg of anthocyanins. Fasting plasma levels of glucose, insulin, HgbA 1C , and triglyceride as well as 2-hour postprandial glucose level (2Hpp) were measured before and after the intervention and finally the mean values were compared between groups.  Results . After 6 weeks of intervention, significant increase in insulin level (1.13 ± 1.90 versus −0.643 ± 1.82,  P  < 0.05) as well as decrease in HgbA 1C  (−0.24 ± 0.429 versus 0.023 ± 0.225,  P  < 0.05) and TG (−23.66 ± 55.40 versus 2.83 ± 15.71,  P  < 0.05) levels was observed in drug group compared to placebo.  Conclusion . Daily consumption of the fruit extract of  Cornus mas  L. improves glycemic control by increasing insulin level and reduces TG serum level in type 2 diabetic adult patients.

evidence-based complementary and alternative medicine

Evaluation of the Effects of<i>Cornus mas</i>L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Evaluation of the Effects ofCornus masL. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial