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Aim of Study .  Moringa oleifera  Lam. ( M. oleifera ) possess highest concentration of antioxidant bioactive compounds and is anticipated to be used as an alternative medicine for inflammation. In the present study, we investigated the anti-inflammatory activity of 80% hydroethanolic extract of  M. oleifera  flower on proinflammatory mediators and cytokines produced in lipopolysaccharide- (LPS-) induced RAW 264.7 macrophages.  Materials and Methods . Cell cytotoxicity was conducted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Nitric oxide (NO) production was quantified through Griess reaction while proinflammatory cytokines and other key inflammatory markers were assessed through enzyme-linked immunosorbent assay (ELISA) and immunoblotting.  Results . Hydroethanolic extract of  M. oleifera  flower significantly suppressed the secretion and expression of NO, prostaglandin E 2  (PGE 2 ), interleukin- (IL-) 6, IL-1 β , tumor necrosis factor-alpha (TNF- α ), nuclear factor-kappa B (NF- κ B), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2). However, it significantly increased the production of IL-10 and I κ B- α  (inhibitor of  κ B) in a concentration dependent manner (100  μ g/mL and 200  μ g/mL).  Conclusion . These results suggest that 80% hydroethanolic extract of  M. oleifera  flower has anti-inflammatory action related to its inhibition of NO, PGE 2 , proinflammatory cytokines, and inflammatory mediator's production in LPS-stimulated macrophages through preventing degradation of I κ B- α  in NF- κ B signaling pathway.

mediators of inflammation

<i>Moringa oleifera</i>Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-<i>κ</i>B Pathway

Moringa oleiferaFlower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway