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This study investigates the effect of soothing liver and invigorating spleen recipes on steatohepatitis examining the IKK β -NF- κ B signaling pathway in KCs of NASH rats. SD male rats were randomly divided into 8 groups, and the NASH model was induced by a high-fat diet (HFD). After 26 weeks, liver tissue was examined in H&E stained sections and liver function was monitored biochemically. KCs were isolated by Seglen's method, with some modifications. The mRNA and protein expression of the IKK β -NF- κ B signaling pathway components was examined by quantitative PCR and Western blotting. The results show that the high-fat diet induced NASH in the rats, and the soothing liver recipe and invigorating spleen recipe decreased the levels of TNF- α , IL-1, and IL-6 in KCs, as well as inhibiting the mRNA and protein expression of the IKK β -NF- κ B signaling pathway components. In conclusion, the experiment indicated the importance of the IKK β -NF- κ B signaling pathway in KCs for the anti-inflammatory effects of the soothing liver and invigorating spleen recipes.

evidence-based complementary and alternative medicine

Effects of Soothing Liver and Invigorating Spleen Recipes on the IKK<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mo mathvariant="bold">β</mml:mo></mml:mrow></mml:math>-NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mo mathvariant="bold">κ</mml:mo></mml:mrow></mml:math>B Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats

Effects of Soothing Liver and Invigorating Spleen Recipes on the IKKβ-NF-κB Signaling Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis Rats