English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD). Both vitamin D 3  and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS. In vitamin D 3  metabolism, the vitamin D 3  25-hydroxylase (CYP27A1) and 25-hydroxyvitamin D 3  1-alpha-hydroxylase (CYP27B1) are two key enzymes. This study aimed to examine the influence of vitamin D 3  CYP27 single nucleotide polymorphisms (SNPs) on adipocytokines and MetS. Cross-sectional data and DNA samples were collected from male volunteers ( n  = 649, age: 55.7 ± 4.7 years). Two tagging SNPs,  CYP27A1 rs4674344  and  CYP27B1 rs10877012 , were selected from the HapMap project. MetS was significantly associated with the  CYP27A1 rs4674344  SNP ( P  = 0.04) and the ratio of adiponectin/leptin (A/L ratio) was most correlated to the  CYP27A1 rs4674344  SNP, appearing to be significantly lower in T-carriers than in AA subjects (3.7 ± 4.0 versus 5.1 ± 6.0,  P  = 0.001) and significantly negatively associated after adjustment. For each MetS component associated with the  CYP27A1 rs4674344  SNP, the A/L ratios were significantly negative in preclinical stage (condition not meeting the individual criteria), except the blood pressure. In conclusion,  CYP27A1 rs4674344  SNP, A/L ratio, and MetS are significantly associated and T-carriers might have a higher risk of developing MetS due to low A/L ratios in the preclinical stage.

international journal of endocrinology

The Associations of Novel Vitamin D<sub>3</sub>Metabolic Gene<i>CYP27A1</i>Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

The Associations of Novel Vitamin D3Metabolic GeneCYP27A1Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

The Associations of Novel Vitamin D₃Metabolic GeneCYP27A1Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males