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Objective . To investigate the effect of  α -allocryptopine (ALL) on delayed afterdepolarization (DAD) incidence and triggered activity (TA) in mice administered isoproterenol (ISO).  Methods . Mouse ventricular myocytes were isolated. And the cellular electrophysiological properties of ventricular myocytes were investigated.  Results . We found that the incidences of DADs and TA in mouse myocytes were increased by ISO treatment. In sharp contrast, triggered arrhythmia events were rarely observed in myocytes with 10  μ M ALL treatment. Transient inward current ( I   ti ) was reduced significantly with ALL treatment, which contributed to DAD-related triggered arrhythmia. Compared to Iso-treated group, the L-type calcium current ( I   Ca,L ) densities were decreased after exposure to ALL, along with slower activation, quicker inactivation, and longer time constant of recovery from inactivation kinetics.  Conclusion . There is less triggered arrhythmia events in ventricular myocytes treated with ALL. This effect may be associated with the inhibition of  I   ti  and  I   Ca,L .

Effect ofα-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol