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This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3 α ) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3 α  and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3 α  was significantly associated with TNM stage in patients with NPC ( P  < 0.05). NPC patients with positive expression of MIP-3 α  exhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months,  P  = 0.013; DMFS: 50.1 months versus 60.2 months,  P  = 0.003). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months,  P  = 0.004; LRFS: 54.5 months versus 59.5 months,  P  = 0.036; DMFS: 52.3 months versus 58.8 months,  P  = 0.036). Both MIP-3 α  and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3 α  and cystatin A expressions may be valuable prognostic markers in NPC patients.

Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma