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Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1 α ) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1 α  in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.

Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1αin Psoriasis