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Objectives . To evaluate the differences in prognostic values of static and dynamic PET-CT in nasopharyngeal carcinoma (NPC).  Material and Methods . Forty-five patients who had static scan were recruited. Sixteen had dynamic scan. The primary lesions were delineated from standardized uptake value (SUV) maps from static scan and  K    i   maps from dynamic scan. The average follow-up lasted for 34 months. The patients who died or those with recurrence/residual disease were considered “poor outcome”; otherwise they were considered “good outcome.” Fisher's exact test and ROC analysis were used to evaluate the prognostic value of various factors.  Results . Tumor volume thresholded by 40% of maximal SUV (VOL SUV40 ) significantly predicted treatment outcome ( p  = 0.024) in the whole cohort. In 16 patients with dynamic scan, all parameters by dynamic scan were insignificant in predicting the outcome. The combination of maximal SUV, maximal  K    i  , VOL SUV40 , and VOL  K   i  37  (the tumor volume thresholded by 37% maximal  K    i  ) achieved the highest predicting accuracy for treatment outcome with sensitivity, specificity, and accuracy of 100% in these 16 patients; however this improvement compared to VOL SUV40  was insignificant.  Conclusion . Tumor volume from static scan is useful in NPC prognosis. However, the role of dynamic scanning was not justified in this small cohort.

Prognostic Value of18F-FDG PET-CT in Nasopharyngeal Carcinoma: Is Dynamic Scanning Helpful?

Prognostic Value of¹⁸F-FDG PET-CT in Nasopharyngeal Carcinoma: Is Dynamic Scanning Helpful?