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Purpose . To investigate the effect of laser peripheral iridotomy (LPI) in subgroups of primary angle closure based on iris insertion configuration.  Methods . Anterior segment optical coherence tomography (AS-OCT) images were obtained before and two weeks after LPI. Qualitative classification of angle closure eyes according to iris insertion (basal insertion group (BG) and nonbasal insertion group (NBG)) was performed. Anterior chamber depth (ACD), lens vault (LV), iris curvature, iris area, iris thickness (IT 750 ), and angle opening distance (AOD 750 ) 750 microns from scleral spur were calculated. Uni- and multivariate regression analysis was carried out to evaluate factors associated with AOD 750  before and after LPI.  Results . Ninety-two eyes of 92 subjects were categorized as NBG (39 eyes) or BG (53 eyes). The mean change after LPI was not significantly different between two groups in all parameters. In both groups, AOD 750  was affected by ACD ( p  < 0.001,  p  = 0.044) before LPI. AOD 750  was affected by LV ( p  = 0.012) in NBG, but by ACD ( p  < 0.001) and IT 750  ( p  = 0.039) in BG after LPI.  Conclusions . The outcomes of LPI are not significantly different between angle closure subgroups with different iris insertions. However, factors affecting AOD 750  show differences between two subgroups after LPI.

Effects of Laser Peripheral Iridotomy in Subgroups of Primary Angle Closure Based on Iris Insertion