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Purpose . Manganese-enhanced MRI (MEMRI) has been applied to a wide range of biological and disease research. The purpose of the study was to use MEMRI to diagnose the acute mesenteric ischemia (AMI).  Methods . The institutional experimental animal ethics committee approved this study. To optimize the dose of Mn 2+  infusion, a dose-dependent curve was obtained using Mn 2+ -enhanced  T   1  map MRI by an intravenous infusion 2.5–20 nmol/g body weight (BW) of 50 nmol/L MnCl 2 . The eighteen animals were divided into control, sham-operated, and AMI groups. AMI models were performed by ligating the superior mesenteric artery (SMA).  T   1  values were measured on  T   1  maps in regions of the small intestinal wall and relaxation rate (Δ R   1 ) was calculated.  Results . A nonlinear relationship between infused MnCl 2  solution dose and increase in small intestinal wall Δ R   1  was observed. Control animal exhibited significant Mn 2+  clearance over time at the dose of 15 nmol/g BW. In the AMI model, Δ R   1  values (0.95 ± 0.13) in the small intestinal wall were significantly lower than in control group (2.05 ± 0.19) after Mn 2+  infusion ( P  < 0.01).  Conclusion . The data suggest that MEMRI shows potential as a diagnostic technique that is directly sensitive to the poor or absent perfusion in AMI.

A New Approach Using Manganese-Enhanced MRI to Diagnose Acute Mesenteric Ischemia in a Rabbit Model: Initial Experience