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Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na 18 F −  PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The SUV  m  ( t ) ( m  = max, mean) and a series of slopes were computed as (SUV  m  ( t    i  ) − SUV  m  ( t    j  ))/( t    i   −  t    j  ), for pairs of time values  t    i   and  t    j  . A Patlak-like analysis was performed for the same time values by computing ((VOI  p  ( t    i  )/VOI  e  ( t    i  ))−(VOI  p  ( t    j  )/VOI  e  ( t    j  )))/( t    i   −  t    j  ), where  p  = broken bone, other bone, and muscle and  e  = expected activity in a VOI. Paired comparisons between Patlak-like and SUV  m   slopes showed good agreement by both linear regression and correlation coefficient analysis ( r  = 84%,  r    s   = 78%-SUV max ,  r  = 92%, and  r    s   = 91%-SUV mean ), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min −1  or greater between examinations and SUV max  differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min −1  usually indicated poor remodeling progress in this cohort.

Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences