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Tricholoma matsutake  has been popular as food and biopharmaceutical materials in Asian countries for its various pharmacological activities. The present study aims to analyze the antifatigue effects on enhancing exercise performance of  Tricholoma matsutake  fruit body (ABM) and liquid cultured mycelia (TM) in mouse model. Two-week  Tricholoma matsutake  treatment significantly enhances the exercise performance in weight-loaded swimming, rotating rod, and forced running test. In TM- and ABM-treated mice, some factors were observed at 60 min after swimming compared with nontreated mice, such as the increased levels of adenosine triphosphate (ATP), antioxidative enzymes, and glycogen and the reduced levels of malondialdehyde and reactive oxygen species in muscle, liver, and/or serum. Further data obtained from western blot show that CM and ABM have strongly enhanced the activation of 5′-AMP-activated protein kinase (AMPK), and the expressions of peroxisome proliferator have activated receptor  γ  coactivator-1 α  (PGC-1 α ) and phosphofructokinase-1 (PFK-1) in liver. Our data suggest that both  Tricholoma matsutake  fruit body and liquid cultured mycelia possess antifatigue effects related to AMPK-linked antioxidative pathway. The information uncovered in our study may serve as a valuable resource for further identification and provide experimental evidence for clinical trials of  Tricholoma matsutake  as an effective agent against fatigue related diseases.

Antifatigue Activity of Liquid CulturedTricholoma matsutakeMycelium Partially via Regulation of Antioxidant Pathway in Mouse