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Diabetes mellitus is regarded as a serious chronic disease that carries a high risk for considerable complications. In folk medicine, the edible  Grewia asiatica  fruit is used in a number of pathological conditions. This study aimed to investigate the possible curative effect of  G. asiatica  fruit ethanolic extract against streptozotocin- (STZ-) induced hyperglycemia in rats. Furthermore, mechanism of antihyperglycemic action is investigated. Hyperglycemic rats are either treated with 100 or 200 mg/kg/day  G. asiatica  fruits extract. Serum glucose, liver glycogen, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), interleukin- (IL-) 1 β , and tumor necrosis factor- (TNF-)  α  are measured.  G. asiatica  fruits extract reduces blood glucose and pancreatic MDA levels. It increases liver glycogen and pancreatic GSH contents and SOD enzyme activity. Furthermore,  Grewia asiatica  fruits extract decreases serum IL-1 β  and TNF- α . The treatment also protects against STZ-induced pathological changes in the pancreas. The results of this study indicated that  G. asiatica  fruit extract exerts antihyperglycemic activity against STZ-induced hyperglycemia. The improvement in the pancreatic  β -cells and antioxidant and anti-inflammatory effects of  G. asiatica  fruit extract may explain the antihyperglycemic effect.

oxidative medicine and cellular longevity

Antihyperglycemic Potential of<i>Grewia asiatica</i>Fruit Extract against Streptozotocin-Induced Hyperglycemia in Rats: Anti-Inflammatory and Antioxidant Mechanisms

Antihyperglycemic Potential ofGrewia asiaticaFruit Extract against Streptozotocin-Induced Hyperglycemia in Rats: Anti-Inflammatory and Antioxidant Mechanisms