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Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H 2 O 2  production and its association with p 66Shc , FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were subjected to an acute exercise. Muscle tissues (gastrocnemius and quadriceps femoris) were taken after exercise to measure mitochondrial H 2 O 2  content, expression of p 66Shc  and FOXO3a, and the activity of antioxidant enzymes. The results showed that acute exercise significantly increased mitochondrial H 2 O 2  content and expressions of p 66Shc  and FOXO3a in a time-dependent manner, with a linear correlation between the increase in H 2 O 2  content and p 66Shc  or FOXO3a expression. The activity of mitochondrial catalase was slightly reduced in the 90 min exercise group, but it was significantly higher in groups with 120 and 150 min exercise compared to that of 90 min exercise group. The activity of SOD was not significantly affected. The results indicate that acute exercise increases mitochondrial H 2 O 2  production in the skeletal muscle, which is associated with the upregulation of p 66Shc  and FOXO3a. The association of p 66Shc  and FOXO3a signaling with exercise induced H 2 O 2  generation may play a role in regulating cellular oxidative stress during acute exercise.

oxidative medicine and cellular longevity

Acute Exercise Induced Mitochondrial H2O2Production in Mouse Skeletal Muscle: Association with p66Shcand FOXO3a Signaling and Antioxidant Enzymes