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Purpose . To determine changes in central subfield (CSF) macular thickness and best corrected visual acuity (BCVA) following single session, multispot panretinal photocoagulation (PRP).  Methods . Forty eyes of 33 patients with newly diagnosed proliferative diabetic retinopathy were treated with single session, 20-millisecond, multispot PRP. Changes in central macular thickness and BCVA at 4- and 12-week follow-up were compared to baseline measurements.   Results . Each eye received a mean (SD) of 2,750 (686.7) laser spots. At 4-week follow-up, there was a statistically significant 24.0  μ m increase in mean CSF thickness ( P  = 0.001), with a 17.4  μ m increase from baseline at 12-week follow-up ( P  = 0.002). Mean logMAR BCVA increased by 0.05 logMAR units ( P  = 0.03) at 4-week follow-up. At 12-week follow-up, BCVA had almost returned to normal with only an increase of 0.02 logMAR units compared to baseline ( P  = 0.39). Macular edema occurred in 2 eyes (5%) at 12-week follow-up.  Conclusions . Macular thickening occurs following single session, 20-millisecond, multispot PRP, with a corresponding, mild change in BCVA. However, the incidence of macular edema appears to be low in these patients. Single session, 20-millisecond, multispot PRP appears to be a safe treatment for patients with proliferative diabetic retinopathy.

Changes in Central Macular Thickness following Single Session Multispot Panretinal Photocoagulation