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The traditional herb  Plumula Nelumbinis  is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of  Plumula Nelumbinis  on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of  Plumula Nelumbinis  (CEPN) was prepared, which completely inhibited precontraction induced by high K +  in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca 2+  channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca 2+  influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

Relaxant Action ofPlumula NelumbinisExtract on Mouse Airway Smooth Muscle