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Context .  Clostridium perfringens  septicemia is often associated with translocation from the gastrointestinal or gastrourinary tract and occurs in patients who have malignancy or are immunocompromised.  Clostridium perfringens  septicemia is usually fatal without early identification, source control, and antibiotics.  Case . We present a case of a 65-year-old female with  Clostridium perfringens  septicemia secondary to emphysematous cholecystitis, with progression to hepatic abscesses.  Conclusion . Septicemia secondary to  Clostridium perfringens  is generally fatal if not detected early. Source control with surgery or percutaneous drainage and early antibiotic therapy is imperative. Hyperbaric oxygen therapy may reduce mortality. Clinicians caring for patients with sepsis and intravascular hemolysis must have  Clostridium perfringens  septicemia on their differential diagnosis with a low threshold for starting antibiotics and pursuing source of infection.

Intravascular Hemolysis and Septicemia due toClostridium perfringensEmphysematous Cholecystitis and Hepatic Abscesses