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Nonalcoholic steatohepatitis (NASH) has become a global chronic liver disease, but no effective medicine has been proven to cure it. This study investigated the protective effects of genistein, a phytoestrogen, on NASH and examined whether it has any effect on hepatic PPAR γ . Male Sprague-Dawley rats were divided into four groups: control group fed ad libitum with standard rat diet, NASH group fed ad libitum with high-fat diet to induce NASH and NASH + Gen8 group and NASH + Gen16 group fed with high-fat diet plus intragastric administration of 8 or 16 mg/kg genistein once daily. After 6 weeks, liver samples were collected to determine MDA, TNF- α , PPAR γ , and histopathology. The findings were that levels of hepatic MDA and TNF- α  increased in NASH group, but 16 mg/kg genistein reduced these levels significantly. Downregulation of hepatic PPAR γ  was observed in NASH group, but genistein significantly upregulated the expression of PPAR γ  in both NASH + Gen groups. The histological appearance of liver in NASH group presented pathological features of steatohepatitis which were diminished in both NASH + Gen groups. The results suggest that genistein attenuates the liver histopathology of NASH with upregulation of hepatic PPAR γ , reduction of oxidative stress, and inhibition of inflammatory cytokine.

Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγin a Rat Model