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Previously, we reported that a compound from a group of thiohydrazides of oxamic acids, CL-55, possessed antichlamydial activity  in vitro  that was accompanied by a decreased translocation of the type three secretion effector, IncA, into the host cell. In this study, the antichlamydial activity of CL-55 was tested  in vivo  in DBA/2 mice infected with  C. trachomatis  serovar D. We found that intravaginal inoculation of DBA/2 mice with the clinically relevant strain,  C. trachomatis  serovar D, results in a course of infection and pathology similar to that observed in humans. The early stage of infection in this model was characterized by a shedding of  Chlamydia  in vaginal secretions followed by an ascending infection and inflammation in the upper genital tract. We found that CL-55 possessed antibacterial activity  in vivo  and was able to control  C. trachomatis  vaginal shedding, ascending infection, and inflammation in the upper genital organs in DBA/2 mice. Our data provide a proof of concept for the protective effect of the thiadiazinon, CL-55, against chlamydial infection  in vivo  and support the feasibility of further studies of its potential therapeutic applications.

biomed research international

Small Molecule Inhibitor of Type Three Secretion Suppresses Acute and Chronic<i>Chlamydia trachomatis</i>Infection in a Novel Urogenital Chlamydia Model

Small Molecule Inhibitor of Type Three Secretion Suppresses Acute and ChronicChlamydia trachomatisInfection in a Novel Urogenital Chlamydia Model