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Purpose . Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer. The present work investigated the effect of 3,3′-diindolylmethane (DIM) on  γ -irradiation sensitizing human breast carcinoma.  Methods . Cell survival, intracellular ROS levels, cell cycle distribution, cell apoptosis, and expression of proteins related to apoptosis were measured with MTT assays, flow cytometry, and Western blot analysis, respectively.  Results .  In vitro  DIM plus  γ -irradiation arrested the activity of G2/M phase cell cycle, increased intracellular ROS level, significantly suppressed PARP (poly ADP-ribose polymerase), and enhanced  γ -irradiation-induced apoptosis, thereby inhibiting the proliferation of MCF-7 cells.  Conclusion . These data provide a rationale for the use of DIM as a promising sensitizer of  γ -irradiation.

3,3′-Diindolylmethane: A Promising Sensitizer ofγ-Irradiation