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Objectives . The aim of this study is researching the role of the Regulatory T cell (Treg)/T helper cell-17 (Th17) cell ratio imbalance in the pathogenesis of autoimmune hepatitis (AIH) and the use of the “Bu Xu Hua Yu” recipe in the treatment of AIH.  Materials and Methods . Sixty adult male C57/BL6 mice were divided into six different groups.  α -Galcer was injected abdominally for production of the animal models. Liver function tests, histological examinations, liver tissue Regulatory T cell, and T helper cell-17 levels tests were carried out. TGF- β 1, IL-10, IL-17, and expression of mRNA and protein levels of Foxp3 and ROR- γ t were also assessed.  Results . Bu Xu Hua Yu method increased the levels of Regulatory T cell, IL-10, and the expression of Foxp3 ( P  < 0.05) in mice liver tissues. Furthermore, there were decreases in the levels of T helper cell-17, IL-17, and expression of ROR γ t mRNA and protein ( P  < 0.05). The ratio of Treg/Th17 was increased ( P  < 0.05).  Conclusion . Mice with AIH have a Treg/Th17 ratio imbalance. Bu Xu Hua Yu method was able to restore the cellular balance of Treg/Th17 through the regulation of the expression of ROR γ t and Foxp3 and can play an important role in the treatment of AIH.

Chinese Medicine Bu Xu Hua Yu Recipe for the Regulation of Treg/Th17 Ratio Imbalance in Autoimmune Hepatitis