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The magnitude of  Leptospira  exposure in rural Mexico is largely unknown. We sought to determine the seroprevalence of  Leptospira  IgG antibodies in adults in rural Durango, Mexico, and to determine the sociodemographic, behavioral, and housing characteristics of the subjects associated with  Leptospira  seropositivity. We performed a cross-sectional study in 282 adults living in rural Durango, Mexico. Sera from participants were analyzed for  Leptospira  IgG antibodies using a commercially available enzyme immunoassay. Seroprevalence association with the characteristics of the subjects was analyzed by bivariate and multivariate analyses. Of the 282 rural subjects (42.91 ± 17.53 years old) studied, 44 (15.6%) had anti- Leptospira  IgG antibodies. Seropositivity to  Leptospira  was not associated with gender, educational level, employment, socioeconomic status, contact with animals or soil, or type of floors at home. In contrast, multivariate analysis showed that  Leptospira  exposure was associated with national trips (OR = 2.09; 95% CI: 1.05–4.16;  P  = 0.03) and poor education of the head of the family (OR = 2.96; 95% CI: 1.51–5.78;  P  = 0.001). We demonstrated serological evidence of  Leptospira  exposure in adults in rural northern Mexico. The contributing factors associated with  Leptospira  exposure found in the present study may be useful for optimal planning of preventive measures against  Leptospira  infection.

Seroepidemiology ofLeptospiraExposure in General Population in Rural Durango, Mexico