English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background . To conduct a systematic review and meta-analysis of clinical trials for eradication of  Helicobacter pylori  ( H. pylori ) that included a treatment arm with a proton pump inhibitor, rifabutin, and amoxicillin.  Materials and Methods . We selected clinical trials that examined the efficacy of  H. pylori  eradication therapies and included a study arm using the test regimen from major medical literature databases and abstracts from major gastroenterology meetings. We also did subgroup and sensitivity analyses.  Results . Twenty-one studies were included in systematic review. The total eradication rates of the test regimen were 70.4% by intent-to-treat (ITT) and 72.0% by per-protocol (PP) analyses. The pooled odds ratio (OR) was 0.55 using fixed effects model ( P  = 0.283) for the test regimen versus other triple regimens. The total eradication rates were 68.4% for the test regimen and 81.9% in the control group by ITT, while the OR was 1.08 using random effects model ( P  = 0.019). The pooled eradication rate was 66.4% for the test regimen and 67.4% for the control group by ITT. The total adverse effects incidence were 25.1% for the test regimen.  Conclusions . The test regimen for  H. pylori  rescue therapy may be not superior to control regimens in efficacy.

gastroenterology research and practice

Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for<i>Helicobacter pylori</i>Infection: A Systematic Review and Meta-Analysis

Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin forHelicobacter pyloriInfection: A Systematic Review and Meta-Analysis