English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Proper control of Ca 2+  signaling is mandatory for effective cell migration, which is critical for embryonic development, wound healing, and cancer metastasis. However, how Ca 2+  coordinates structural components and signaling molecules for proper cell motility had remained elusive. With the advance of fluorescent live-cell Ca 2+  imaging in recent years, we gradually understand how Ca 2+  is regulated spatially and temporally in migrating cells, driving polarization, protrusion, retraction, and adhesion at the right place and right time. Here we give an overview about how cells create local Ca 2+  pulses near the leading edge, maintain cytosolic Ca 2+  gradient from back to front, and restore Ca 2+  depletion for persistent cell motility. Differential roles of Ca 2+  in regulating various effectors and the interaction of roles of Ca 2+  signaling with other pathways during migration are also discussed. Such information might suggest a new direction to control cancer metastasis by manipulating Ca 2+  and its associating signaling molecules in a judicious manner.

Ca2+Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis

Ca²⁺Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis