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The present study aimed to evaluate antioxidant and acetylcholinesterase (AChE) inhibitory activities of the ethanolic extracts of six selected  Thymus  species growing in Croatia ( T. longicaulis ,  T. praecox  subsp.  polytrichus ,  T. pulegioides ,  T. serpyllum  subsp.  serpyllum ,  T. striatus , and  T. vulgaris ). Antioxidant effectiveness was assessed using six different assays, in comparison with rosmarinic acid, luteolin, and reference antioxidants. All tested  Thymus  extracts possessed DPPH (IC 50  = 3–6  μ g/mL) and nitric oxide (IC 50  = 70–177  μ g/mL) free radical scavenging activities, strong reducing properties (IC 50  = 11–15  μ g/mL), ferrous ion chelating activity (IC 50  = 126–389  μ g/mL), ability to inhibit lipid peroxidation (IC 50  = 34–80  μ g/mL), and high total antioxidant capacities (238–294 mg AAE/g). AChE inhibitory activity was examined using Ellman's colorimetric method and all tested extracts showed anti-AChE activity in a dose dependent manner. The values of 10–28%, 23–39%, and 64–86% were obtained for tested concentrations of 0.25, 0.5, and 1 mg/mL, respectively. Additionally, the contents of total hydroxycinnamic derivatives, flavonoids, and tannins in dried plant samples were determined spectrophotometrically. Our results highlighted  Thymus  species as a rich source of natural antioxidants and AChE inhibitors that could be useful in preventing and treating Alzheimer's disease and other neurodegenerative disorders.

Antioxidant and Anticholinesterase Potential of SixThymusSpecies