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Objective . To compare fourier-domain optical coherence tomography (FD-OCT) and time-domain OCT (TD-OCT) in the determination of thinnest corneal thickness (TCT).  Methods . This study included 55 keratoconus patients and 50 healthy volunteers. The RTVue-OCT (FD-OCT) and Visante-OCT (TD-OCT) were used for the measurement of the TCT. Three consecutive scans were performed. The comparison and agreement between the two modalities were analyzed by paired  t -test, the Pearson correlation, intraclass correlation coefficient (ICC), and Bland-Altman plots. intraobserver repeatability was analyzed by the intraobserver within-subject standard deviation ( S   ( w ) ), coefficient of variation (CV ( w ) ), and ICC.  Results . The TCT value of normal corneas was higher by RTVue-OCT (530.4 ± 19.7  μ m) than Visante-OCT (521.5 ± 18.3  μ m) ( p  < 0.001). For keratoconus eyes, the TCT was 425.0 ± 58.2  μ m and 424.4 ± 55.7  μ m (difference being 0.6 ± 10.2  μ m,  p  = 0.604). Strong correlation ( r  = 0.938∼0.985) (ICC = 0.915–0.984) was observed between the two OCTs, and each OCT exhibited excellent repeatability in determining the TCT in all subjects (ICC = 0.984–0.994).  Conclusions . The values of TCT obtained from RTVue-OCT and Visante-OCT were highly correlated; however, the two values were different. Both OCT instruments exhibited good intraobserver reliability. The existence of systematic differences suggested that the two instruments cannot be used interchangeably.

Comparison of Fourier-Domain and Time-Domain Optical Coherence Tomography in the Measurement of Thinnest Corneal Thickness in Keratoconus