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To better understand the molecular events underlying vulvovaginal candidiasis, we established an  in vitro  system. Immortalized vaginal epithelial cells were infected with live, yeast form  C. albicans  and  C. albicans  cultured in the same medium without vaginal epithelial cells were used as control. In both cases a yeast to hyphae transition was robustly induced. Whole transcriptome sequencing was used to identify specific gene expression changes in  C. albicans . Numerous genes leading to a yeast to hyphae transition and hyphae specific genes were upregulated in the control hyphae and the hyphae in response to vaginal epithelial cells. Strikingly, the GlcNAc pathway was exclusively triggered by vaginal epithelial cells. Functional analysis in our  in vitro  system revealed that the GlcNAc biosynthesis is involved in the adherence to, and the ability to kill, vaginal epithelial cells  in vitro , thus indicating the key role for this pathway in the virulence of  C. albicans  upon vulvovaginal candidiasis.

biomed research international

The Absence of N-Acetyl-D-glucosamine Causes Attenuation of Virulence of<i>Candida albicans</i>upon Interaction with Vaginal Epithelial Cells<i>In Vitro</i>

The Absence of N-Acetyl-D-glucosamine Causes Attenuation of Virulence ofCandida albicansupon Interaction with Vaginal Epithelial CellsIn Vitro