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Background and Objectives. To evaluate the clinical effectiveness and safety of using nanocomposite bone material in the repair of large proximal femoral defects that are due to fibrous dysplasia. Method. Thirty-one patients were analyzed retrospectively, including 13 males and 18 females, and the mean age was 30.9 years (13–59). The median follow-up period was 50 months (30–78) and the masses of artificial bone transplants were in the range of 15~40 g (average of 23.4 g). Functional and radiographic outcomes were evaluated. Results. All wounds healed to grade A. There were no infections, nonspecific inflammatory reactions, rejection reactions, or fractures. One case had fat liquefaction and healed after dressing. All patients had no recurrence until the last follow-up. At the last follow-up, the mean Musculoskeletal Tumor Society’s (MSTS) 93 score was 28.42 ± 1.31, the mean Harris hip score was 84.23 ± 8.97, and mean radiopaque density ratio was 0.78 ± 0.09. Radiologic analysis indicated that nanocomposite bone material had been completely incorporated with the host bone within a year. Conclusions. This study indicated that the nanocomposite bone material had biological safety and good biocompatibility. In conclusion, the nanocomposite bone material is an ideal artificial bone substitute and worthy of promotion in the field of orthopedics.

Interim Clinical Outcomes in Nanocomposite Bone Material Repairing Large Proximal Femoral Defect of Fibrous Dysplasia