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We investigated  T   1  relaxations of  ex-vivo  cancer tissues at low magnetic fields in order to check the possibility of achieving a  T   1  contrast higher than those obtained at high fields. The  T   1  relaxations of fifteen pairs (normal and cancerous) of breast tissue samples were measured at three magnetic fields, 37, 62, and 122  μ T, using our superconducting quantum interference device-based ultralow field nuclear magnetic resonance setup, optimally developed for  ex-vivo  tissue studies. A signal reconstruction based on Bayesian statistics for noise reduction was exploited to overcome the low signal-to-noise ratio. The ductal and lobular-type tissues did not exhibit meaningful  T   1  contrast values between normal and cancerous tissues at the three different fields. On the other hand, an enhanced  T   1  contrast was obtained for the mucinous cancer tissue.

biomed research international

<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>Relaxation Measurement of<i>Ex-Vivo</i>Breast Cancer Tissues at Ultralow Magnetic Fields

T1Relaxation Measurement ofEx-VivoBreast Cancer Tissues at Ultralow Magnetic Fields