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Fragile X mental retardation protein (FMRP) is a neuronal translational repressor and has been implicated in learning, memory, and cognition. However, the role of  Bacopa monnieri  extract (CDRI-08) in enhancing cognitive abilities in hypoxia-induced memory impairment via  Fmr-1  gene expression is not known. Here, we have studied effects of CDRI-08 on the expression of  Fmr-1  gene in the hippocampus of well validated cobalt chloride (CoCl 2 )-induced hypoxia mimetic mice and analyzed the data with alterations in spatial memory. Results obtained from Morris water maze test suggest that CoCl 2  treatment causes severe loss of spatial memory and CDRI-08 is capable of reversing it towards that in the normal control mice. Our semiquantitative RT-PCR, Western blot, and immunofluorescence microscopic data reveal that CoCl 2 -induced hypoxia significantly upregulates the expression of Hif-1 α  and downregulates the  Fmr-1  expression in the hippocampus, respectively. Further, CDRI-08 administration reverses the memory loss and this is correlated with significant downregulation of Hif-1 α  and upregulation of  Fmr-1  expression. Our data are novel and may provide mechanisms of hypoxia-induced impairments in the spatial memory and action of CDRI-08 in the recovery of hypoxia led memory impairment involving  Fmr-1  gene encoded protein called FMRP.

evidence-based complementary and alternative medicine

A Special Extract ofBacopa monnieri(CDRI-08)-Restored Memory in CoCl2-Hypoxia Mimetic Mice Is Associated with Upregulation ofFmr-1Gene Expression in Hippocampus