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Antrodia camphorata  is a parasitic fungus from Taiwan, it has been documented to possess a variety of pharmacological and biological activities. The present study was undertaken to evaluate the potential of  Antrodia camphorata  ethanol extract to accelerate the rate of wound healing closure and histology of wound area in experimental rats. The safety of  Antrodia camphorata  was determined  in vivo  by the acute toxicity test and  in vitro  by fibroblast cell proliferation assay. The scratch assay was used to evaluate the  in vitro  wound healing in fibroblast cells and the excision model of wound healing was tested  in vivo  using four groups of adult  Sprague Dawley  rats. Our results showed that wound treated with  Antrodia camphorata  extract and intrasite gel significantly accelerates the rate of wound healing closure than those treated with the vehicle. Wounds dressed with  Antrodia camphorata  extract showed remarkably less scar width at wound closure and granulation tissue contained less inflammatory cell and more fibroblast compared to wounds treated with the vehicle. Masson's trichrom stain showed granulation tissue containing more collagen and less inflammatory cell in  Antrodia camphorata  treated wounds. In conclusion,  Antrodia camphorata  extract significantly enhanced the rate of the wound enclosure in rats and promotes the  in vitro  healing through fibroblast cell proliferation.

Application ofAntrodia camphorataPromotes Rat’s Wound HealingIn Vivoand Facilitates Fibroblast Cell ProliferationIn Vitro