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To clarify the potential role of variability within and around the  AKT1  gene in smoking behaviors, we performed a single-nucleotide polymorphism (SNP) analysis of the  AKT1  gene in an elderly Japanese cohort. Genotypes of the rs2498794 SNP, which is located in the fifth intron region of the  AKT1  gene, were marginally but significantly associated with smoking duration in the total 999 samples of former and current smokers. Interestingly, this SNP had a marginally significant association with individual cancer history (past and current), especially in groups with a shorter smoking duration (<44 years) and fewer cigarettes per day (≤20). These data suggest that the rs2498794 polymorphism of the  AKT1  gene is associated with a long smoking duration and may be involved in the predisposition to cancer when the smoking duration is short or the cigarettes per day is rate low.

Association betweenAKT1Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility