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Aim . Qat chewing has been reported to induce subgingival microbial shifts suggestive of prebiotic-like properties. The objective here was to assess the effect of qat chewing on a panel of classical and new putative periopathogens in health and periodontitis.  Materials and Methods . 40 qat chewers and 40 nonchewers, equally stratified by periodontal health status, were recruited. Taqman, real-time PCR was used to quantify total bacteria,  Porphyromonas gingivalis ,  Tannerella forsythia ,  Treponema denticola ,  Parvimonas micra ,  Filifactor alocis , Synergistetes, and TM7s in pooled subgingival biofilm samples. Differences in microbial parameters between the study groups were analysed using ordinal regression.  Results . In health, the qat chewers harboured significantly lower relative counts of  P. gingivalis ,  T. forsythia , Synergistetes, and TM7s after adjustment for multiple comparisons ( P  ≤ 0.007). At nominal significance level, they also carried lower counts of TM7s and  P. micra  ( P  ≤ 0.05). In periodontitis, the chewers had lower counts of all taxa; however, only  T. denticola  withstood correction for multiple comparisons ( P  ≤ 0.0063).  Conclusions . Qat chewing is associated with lower proportions of periopathogens, particularly in subjects with healthy periodontium, which supports previous reports of its prebiotic-like properties. This potentially beneficial biological effect can be exploited by attempting to isolate the active fraction.

Qat Chewing and Periodontal Pathogens in Health and Disease: Further Evidence for a Prebiotic-Like Effect