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Brucea javanica  is a traditional herbal medicine in China, and its antitumor activities are of research interest.  Brucea javanica  oil, extracted with ether and refined with 10% ethyl alcohol from  Brucea javanica  seed, was used to treat hepatoma H22-bearing mice in this study. The antitumor effect and probable mechanisms of the extracted  Brucea javanica  oil were studied in H22-bearing mice by WBC count, GOT, GPT levels, and western blotting. The H22 tumor inhibition ratio of 0.5, 1, and 1.5 g/kg bw  Brucea javanica  oil were 15.64%, 23.87%, and 38.27%.  Brucea javanica  oil could inhibit the involution of thymus induced by H22 tumor-bearing, but it could not inhibit the augmentation of spleen and liver.  Brucea javanica  oil could decrease the levels of WBC count and GOT and GPT in H22-bearing mice. The protein levels of GAPDH, Akt, TGF- β 1, and  α -SMA in tumor tissues decreased after being treated with  Brucea javanica  oil. Disturbing energy metabolism and neoplastic hyperplasia controlled by Akt and immunoregulation activity were its probable antitumor mechanisms in hepatoma H22-bearing mice.

Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice ofBrucea javanicaOil