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This study was conducted to describe the genetic profiles of  E. coli  that colonize asymptomatic pediatric neurogenic bladders.  E. coli  was isolated from 25 of 80 urine samples. Patients were excluded if they presented with symptomatic urinary tract infection or received treatment with antibiotics in the preceding three months. Multiplex PCR was performed to determine  E. coli  phylotype (A, B1, B2, and D) and the presence of seven pathogenicity islands (PAIs) and 10 virulence factors (VFs).  E. coli  strains were predominantly of the B1 and B2 phylotype, with few strains in the A or D phylotype. The PAIs IV 536 , I CFT073 , and II CFT073  had the highest prevalence: 76%, 64%, and 48%, respectively. The PAIs II 536 , I J96 , and II J96  were less prevalent: 28%, 20%, and 24%, respectively. The most prevalent VF was  vat  (40%), while the least prevalent VFs were  sfa  (8%) and  iha  (12%). None of the strains carried the VF  fyuA , which is very common in uropathogenic  E. coli  (UPEC). The genetic profiles of  E. coli  in this cohort seem to be more similar to UPEC than to commensal  E. coli . However, they appear to have reduced virulence potential that allows them to colonize asymptomatically.

Genetic Evaluation ofE. coliStrains Isolated from Asymptomatic Children with Neurogenic Bladders