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This study was designed to determine the antioxidant properties and inhibitory effects of extract from  Moringa oleifera  leaves on angiotensin-I-converting enzyme (ACE) and arginase activities  in vitro . The extract was prepared and phenolic (total phenols and flavonoid) contents, radical (nitric oxide (NO), hydroxyl (OH)) scavenging abilities, and Fe 2+ -chelating ability were assessed. Characterization of the phenolic constituents was done via high performance liquid chromatography-diode array detection (HPLC-DAD) analysis. Furthermore, the effects of the extract on Fe 2+ -induced MDA production in rats' penile tissue homogenate as well as its action on ACE and arginase activities were also determined. The extract scavenged NO  ∗  , OH  ∗  , chelated Fe 2+ , and inhibited MDA production in a dose-dependent pattern with IC 50  values of 1.36, 0.52, and 0.38 mg/mL and 194.23  µ g/mL, respectively. Gallic acid, chlorogenic acid, quercetin, and kaempferol were the most abundant phenolic compounds identified in the leaf extract. The extract also inhibited ACE and arginase activities in a dose-dependent pattern and their IC 50  values were 303.03 and 159.59  µ g/mL, respectively. The phenolic contents, inhibition of ACE, arginase, and Fe 2+ -induced MDA production, and radical (OH  ∗  , NO  ∗  ) scavenging and Fe 2+ -chelating abilities could be some of the possible mechanisms by which  M. oleifera  leaves could be used in the treatment and/or management of erectile dysfunction.

Phenolic Extract fromMoringa oleiferaLeaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues