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GRO β  (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GRO β  expression in gastrointestinal stromal tumors (GIST) or the relationship between GRO β  expression and clinical attributes of GIST. GRO β  expression was examined via immunohistochemical staining of 173 GIST samples using tissue microarray. The relationship between GRO β  expression and relevant patient and tumor characteristics was assessed, using chi-square tests. Univariate and multivariate analysis was carried out using the Cox regression method. High GRO β  cytoplasm staining was detected in 56 (32.4%) specimens; high GRO β  nuclear staining was detected in 64 (37.0%) specimens. High GRO β  cytoplasm staining was significantly associated with patients' age ( P  = 0.043) and tumor location ( P  = 0.014), while high GRO β  nucleus staining was significantly associated with mitotic index ( P  = 0.034), tumor location ( P  = 0.049), and AFIP-Miettinen risk classification ( P  = 0.048). Kaplan-Meier survival curves showed GIST patients with low GRO β  cytoplasm expression ( P  = 0.023) and mitotic index < 6 per 50 HPFs ( P  = 0.026) to have a more favorable prognosis. These findings indicate that GRO β  expression correlates with malignant GIST phenotypes and could be an unfavorable prognostic marker in patients with GIST.

disease markers

Association of High Expression of Gro<i>β</i>with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors

Association of High Expression of Groβwith Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors