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The objective of this study was to compare quinolone resistance and  gyrA  mutations in clinical isolates of  Klebsiella pneumoniae  and  Escherichia coli  from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration. The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined. The mutations in the quinolone resistance-determining regions in  gyrA  gene were detected by PCR and DNA sequencing. Fluoroquinolone resistance and types of  gyrA  mutations in isolates from children and adults were compared and statistically analyzed. No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all  P  > 0.05). The double mutation Ser83→Leu + Asp87→Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively ( P  = 0.5444). Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant  Enterobacteriaceae  isolates. The occurrence of ciprofloxacin resistance and the major types of  gyrA  mutations in the isolates from the children were similar to those from adults. The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance.

biomed research international

Comparative Analysis of Quinolone Resistance in Clinical Isolates of<i>Klebsiella pneumoniae</i>and<i>Escherichia coli</i>from Chinese Children and Adults

Comparative Analysis of Quinolone Resistance in Clinical Isolates ofKlebsiella pneumoniaeandEscherichia colifrom Chinese Children and Adults