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Purpose.  To compare ocular rigidity (OR) and outflow facility (C) in patients with nonproliferative diabetic retinopathy (NPDR) and control subjects.  Methods . Twenty-four patients with NPDR (NPDR group) and 24 controls (control group) undergoing cataract surgery were enrolled. NPDR group was further divided into patients with mild NPDR (NPDR1-group) and patients with moderate and/or severe NPDR (NPDR2-group). After cannulation of the anterior chamber, a computer-controlled device was used to infuse saline and increase the intraocular pressure (IOP) in a stepping procedure from 15 to 40 mmHg. Ocular rigidity and outflow facility coefficients were estimated from IOP and volume recordings.  Results . Ocular rigidity was 0.0205  μ L −1  in NPDR group and 0.0202  μ L −1  in control group ( P  = 0.942). In NPDR1-group, OR was 0.017  μ L −1  and in NPDR2-group it was 0.025  μ L −1  ( P  = 0.192). Outflow facility was 0.120  μ L/min/mmHg in NPDR-group compared to 0.153  μ L/min/mmHg in the control group at an IOP of 35 mmHg ( P  = 0.151). There was no difference in C between NPDR1-group and NPDR2-group ( P  = 0.709).  Conclusions . No statistically significant differences in ocular rigidity and outflow facility could be documented between diabetic patients and controls. No difference in OR and C was detected between mild NPDR and severe NPDR.

Ocular Rigidity and Outflow Facility in Nonproliferative Diabetic Retinopathy