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Sarcoidosis is an inflammatory granulomatous disease with unknown etiology driven by cytokines and chemokines. There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary sarcoidosis, suggesting contribution of miRNAs and transcription factors. We therefore investigated gene expression of 25 inflammation-related miRNAs, 27 cytokines/chemokines/receptors, and a Th1-transcription factor  T-bet  in unseparated BAL cells obtained from 48 sarcoidosis patients and 14 control subjects using quantitative RT-PCR. We then examined both miRNA-mRNA expressions to enrich relevant relationships. This first study on miRNAs in sarcoid BAL cells detected deregulation of  miR-146a ,  miR-150 ,  miR-202 ,  miR-204 , and  miR-222  expression comparing to controls. Subanalysis revealed higher number of  miR-155 ,  let-7c  transcripts in progressing ( n  = 20) comparing to regressing ( n  = 28) disease as assessed by 2-year follow-up. Correlation network analysis revealed relationships between microRNAs, transcription factor  T-bet , and deregulated cytokine/chemokine-receptor network in sarcoid BAL cells. Furthermore,  T-bet  showed more pronounced regulatory capability to sarcoidosis-associated cytokines/chemokines/receptors than miRNAs, which may function rather as “fine-tuners” of cytokine/chemokine expression. Our correlation network study implies contribution of both microRNAs and Th1-transcription factor  T-bet  to the regulation of cytokine/chemokine-receptor network in BAL cells in sarcoidosis. Functional studies are needed to confirm biological relevance of the obtained relationships.

mediators of inflammation

Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor<i>T-bet</i>, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription FactorT-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis