English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aims . To evaluate the antidiabetic effects of  Gynostemma pentaphyllum  ( GP ) in Goto-Kakizaki (GK) rat, an animal model of type 2 diabetes, and to investigate the mechanisms of insulin release.  Methods . Oral glucose tolerance test was performed and plasma insulin levels were measured.  Results . An oral treatment with  GP  (0.3 g/kg of body weight daily) for two weeks in GK rats improved glucose tolerance versus placebo group ( P  < 0.01). Plasma insulin levels were significantly increased in the   GP -treated group. The insulin release from  GP -treated GK rats was 1.9-fold higher as compared to the control group ( P  < 0.001).   GP   stimulated insulin release in isolated GK rat islets at high glucose. Opening of ATP-sensitive potassium (K-ATP) channels by diazoxide and inhibition of calcium channels by nifedipine significantly decreased insulin response to  GP . Furthermore, the protein kinase A (PKA) inhibitor H89 decreased the insulin response to  GP  ( P  < 0.05). In addition,  GP -induced insulin secretion was decreased after preincubation of GK islets with pertussis toxin to inhibit exocytotic G e  proteins ( P  < 0.05).  Conclusion.  The antidiabetic effect of  GP  is associated with the stimulation of insulin release from the islets.   GP -induced insulin release is partly mediated via K-ATP and L-type Ca 2+  channels, the PKA system and also dependent on pertussis toxin sensitive G e -protein.

Evaluation of Antidiabetic Effects of the Traditional Medicinal PlantGynostemma pentaphyllumand the Possible Mechanisms of Insulin Release