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As various new sibling species within the  Scedosporium  spp. have been described recently, this study was conducted to investigate distribution and antifungal susceptibility profiles of the different species of  Scedosporium  spp. in China. Twenty-one clinical strains of  Scedosporium  from China and two strains from Japan were reidentified by MLSA. The analysis included BT2, CAL, RPB, SOD, and ACT and the combination of the five loci.  Pseudallescheria boydii  complex (17 strains) and  S. apiospermum  (6 strains) were identified.  P. boydii  complex included four closely related subgroups:  P. boydii  (9 strains),  P. ellipsoidea  (6 strains),  P. fusoidea  (1 strain), and  P. angusta  (1 strain). There were no significant differences in MICs for neither VOR, POS, nor AMB over all the five species in study. For itraconazole, intraspecific diversity was evident.

Molecular Identification and Susceptibility of Clinically RelevantScedosporiumspp. in China