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The aim of this study was to find out if selected lactic acid bacteria (LAB) strains (antagonistic or nonantagonistic against  H. pylori in vitro ) would differ in their abilities to modulate the DCs maturation profiles reflected by their phenotype and cytokine expression patterns.  Methods . Monocyte-derived DCs maturation was elicited by their direct exposure to the LAB strains of  L. rhamnosus  900 or  L. paracasei  915 (antagonistic and nonantagonistic to  H. pylori , resp.), in the presence or absence of  H. pylori  strain  cagA+ . The DCs maturation profile was assessed on the basis of surface markers expression and cytokines production.  Results . We observed that the LAB strains and the mixtures of LAB with  H. pylori  are able to induce mature DCs. At the same time, the  L. paracasei  915 leads to high IL-10/IL-12p70 cytokine ratio, in contrast to  L. rhamnosus  900.  Conclusions . This study showed that the analyzed lactobacilli strains are more potent stimulators of DC maturation than  H. pylori . Interestingly from the two chosen LAB strains the antagonistic to  H. pylori-L. rhamnosus  strain 900 has more proinflammatory and probably antibactericidal properties.

Lactic Acid Bacteria Strains Exert Immunostimulatory Effect onH. pylori-Induced Dendritic Cells