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Trypanosoma cruzi  infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (H III ) or low (L III ) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain—the high responder lines AIRmax and H III  were resistant. The higher resistance of H III  as compared to L III  mice extended to higher infective doses and was correlated with enhanced production of IFN- γ  and nitric oxide production by peritoneal and lymph node cells, in H III  males and females. We also analyzed the involvement of previously mapped Ab and  T. cruzi  response QTL with the survival of Selection III mice to  T. cruzi  infections in a segregating backcross [F1(H III ×L III ) ×L III ] population. An Ab production QTL marker mapping to mouse chromosome 1 (34.8 cM) significantly cosegregated with survival after acute  T. cruzi  infections, indicating that this region also harbors genes whose alleles modulate resistance to acute  T. cruzi  infection.

Trypanosoma cruziInfection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response