English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between  CAT  C262T,  GPX1  Pro198Leu,  MnSOD  Ala16Val,  GSTM1, GSTT1 , and  GSTP1  Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes of  GPX1, MnSOD, GSTM1 , and  GSTT1  polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of the  GSTP1  Ile105Val gene polymorphisms may be associated with the risk of developing CML (OR = 2.5; 95% CI = 1.08–5.7;  P  value = 0.02), while the heterozygous genotype of the  CAT  C262T polymorphism seems to have a protective effect against CML (OR = 0.59, 95% CI = 0.39–0.89,  P  value = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded that  CAT, GPX, MnSOD, GSTM1 , and  GSTT1  gene polymorphisms are not associated with the risk of CML. Variant genotype of the  GSTP1  Ile105Val gene polymorphisms may contribute to the risk of developing CML.

CAT, GPX1, MnSOD, GSTM1, GSTT1, andGSTP1Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study