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Different parts of the medicinal plant  Zanthoxylum budrunga  Wall enjoy a variety of uses in ethnobotanical practice in Bangladesh. In the present study, a number of phytochemical and pharmacological investigations were done on the ethanol extract of  Z. budrunga  seeds (ZBSE) to evaluate its antinociceptive and antioxidant potential. ZBSE was also subjected to HPLC analysis to detect the presence of some common antioxidants. In acetic acid induced writhing test in mice, ZBSE showed 65.28 and 74.30% inhibition of writhing at the doses of 250 and 500 mg/kg and the results were statistically significant ( P  < 0.001). In hot-plate test, ZBSE raised the pain threshold significantly ( P  < 0.001) throughout the entire observation period. In DPPH scavenging assay, the IC 50  of ZBSE was observed at 82.60  μ g/mL. The phenolic content was found to be 338.77 mg GAE/100 g of dried plant material. In reducing power assay, ZBSE showed a concentration dependent reducing ability. HPLC analysis indicated the presence of caffeic acid with a concentration of 75.45 mg/100 g ZBSE. Present investigation supported the use of  Zanthoxylum budrunga  seed in traditional medicine for pain management. Constituents including caffeic acid and other phenolics might have some role in the observed activity.

Antinociceptive and Antioxidant Activity ofZanthoxylum budrungaWall (Rutaceae) Seeds