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Trichilia emetica  and  Opilia amentacea  traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes.  In vitro  and  in vivo  antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of  Trichilia emetica  and  Opilia amentacea  has been evaluated using   β  -carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of  Trichilia emetica . Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of  Trichilia emetica  and  Opilia amentacea  has been observed. Extract of flavonoid-rich fractions from  Trichilia emetica  shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from  Trichilia emetica  compared to the extract of  Opilia amentacea  are demonstrating antidiabetic potential of  Trichilia emetica  as therapeutic targets for the management of type 2 diabetes.

evidence-based complementary and alternative medicine

Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of<i>Trichilia emetica</i>and<i>Opilia amentacea</i>in an Animal Model of Type 2 Diabetes Mellitus

Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves ofTrichilia emeticaandOpilia amentaceain an Animal Model of Type 2 Diabetes Mellitus