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P. niruri  has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and  in vitro  antioxidant activity of  P. niruri  leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.  Results . Treatment of diabetic male rats with  P. niruri  leaf aqueous extract (200 and 400 mg/kg) for 28 consecutive days prevents the increase in the amount of lipid peroxidation (LPO) product, malondialdehyde (MDA), and the diminution of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity levels in the kidney of diabetic rats. The amount of LPO showed strong negative correlation with SOD, CAT, and GPx activity levels.  P. niruri  leaf aqueous extract exhibits  in vitro  antioxidant activity with IC 50  slightly lower than ascorbic acid. Phytochemical screening of plant extract indicates the presence of polyphenols.  Conclusion .  P. niruri  leaf extract protects the kidney from oxidative stress induced by diabetes.

evidence-based complementary and alternative medicine

Aqueous Extract of<i>Phyllanthus niruri</i>Leaves Displays<i>In Vitro</i>Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats

Aqueous Extract ofPhyllanthus niruriLeaves DisplaysIn VitroAntioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats