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Aristolochia longa  is widely used in traditional medicine in Algeria to treat breast cancer. The aim of the present study was to investigate the response of bone resorption markers to  A. longa  intake by Algerian breast cancer postmenopausal women. According to the  A. longa  intake, breast cancer patients were grouped into  A. longa  group (Al) ( n  = 54) and non- A. longa  group (non-Al) ( n  = 24). 32 women constituted the control group. Bone resorption markers (from urine) pyridinoline (PYD) and deoxypyridinoline (DPD) were determined by HPLC. Serum and urinary creatinine, uric acid, and urea were measured. 1 g of  A. longa  intake resulted in significant rise of renal serum markers and a pronounced increase of bone resorption markers. The intake of  A. longa  roots is detrimental for kidney function and resulted in high bone resorption, maybe due to the reduction in renal function caused by the aristolochic acids contained in the roots.

Response of Bone Resorption Markers toAristolochia longaIntake by Algerian Breast Cancer Postmenopausal Women