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The immunomodulatory properties of a mixture of cysteine peptidases (P1G10) obtained from the fruit lattice of  Carica candamarcensis  were investigated. P1G10 was obtained from fresh latex samples by chromatography in a Sephadex column and initially administered to Swiss mice ( n  = 5; 1 or 10 mg/kg) via i.p. After 30 min, the mice were injected with carrageenan (0.5 mg/mouse) or heat-killed  S.  Typhimurium (10 7  CFU/mL; 100°C/30 min) into the peritoneal cavity. Afterwards, two animal groups were i.p. administered with P1G10 ( n  = 6; 1, 5, or 10 mg/Kg) or PBS 24 hours prior to challenge with live  S.  Typhimurium (10 7  CFU/mL). P1G10 stimulated the proliferation of circulating neutrophils and lymphocytes, 6 h after injection of carrageenan or heat-killed bacteria, respectively. Furthermore, survival after infection was dose-dependent and reached 60% of the animal group. On the other hand, control mice died 1–3 days after infection. The examination of mRNA transcripts in liver cells 24 h after infection confirmed fold variation increases of 5.8 and 4.8 times on average for IL-1 and COX-2, respectively, in P1G10 pretreated mice but not for TNF-  α  , IL-10,   γ  -IFN and iNOS, for which the results were comparable to untreated animals. These data are discussed in light of previous reports.

mediators of inflammation

Peptidases from Latex of<i>Carica candamarcensis</i>Upregulate COX-2 and IL-1 mRNA Transcripts against<i>Salmonella enterica</i>ser. Typhimurium-Mediated Inflammation

Peptidases from Latex ofCarica candamarcensisUpregulate COX-2 and IL-1 mRNA Transcripts againstSalmonella entericaser. Typhimurium-Mediated Inflammation